THE STUDY OF THE EFFECT OF SUBCUTANEOUS IMPLANTATION OF INNOVATIVE CARBON
NANOCOMPOSITES ON ANTIOXIDANT STATUS CHANGE IN THE RATS' BRAIN 

Yastremskaya Yana Pavlovna, Undergraduate student, Penza State University (40 Krasnaya street, Penza, Russia), yana1991bio@mail.ru
Lyubchenko Olesya Dmitrievna, Postgraduate student, Penza State University (40 Krasnaya street, Penza, Russia), filology@inbox.ru 

577

Background. The authors investigated innovative carbon nanocomposites for medicine, undergoing preliminary pre-clinical testing, in order to additionaly confirm biocompatibility and absence of delayed toxic effects.
Materials and methods. The researchers subcutaneously implanted innovative carbon nanocomposites: a carbonaceous material with double carbide, a carbon nanocomposite of enhanced strength using fullerenes and nanotubes. The authors researched indices of the antioxidant system after 2 weeks, 4 weeks, 3 months and 6 months since implantation.
Results. It is shown that there has been revealed no delayed toxic effects after implantation of innovative carbon nanocomposites.
Conclusions. The results obtained are in general well-correlated with the results of researching clinical indices in animal serum after implantation.

carbon nanocomposites, implantation, antioxidant system, brain, biocompatibility.

1. Solov'ev V. B. Rol' peptidergicheskoy sistemy v adaptatsionnykh protsessakh i regulyatsii metabolizma pri fizicheskoy rabote: avtoref. dis. d-ra biolog. nauk [Role of peptidergic system in adaptation and regulation of metabolism at physical work: author’s abstract of dissertation to apply for the degree of the doctor of biological sciences]. Peoples’ Fiendship University of Russia. Moscow, 2011, 46 p.
2. Velichko A. K., Solov'ev V. B., Gengin M. T. Izvestiya Penzenskogo gosudarstvennogo pedagogicheskogo universiteta im. V. G. Belinskogo. Estestvennye nauki [Proceedings of Penza State Pedagogical University named after V. G. Belinsky. Natural sciences]. 2009, no. 14 (18), pp. 44–48.
3. Lyubchenko O. D., Solov'ev V. B., Tatarinov V. F. Aktual'nye problemy gumanitarnykh i estestvennykh nauk [Topical problems of humanities and natural sciences]. 2014, no. 6, pp. 82–86.
4. Lyubchenko O. D., Solov'ev V. B., Tatarinov V. F., Yastremskaya Ya. P. Biologiya – nauka XXI veka: 18-ya Mezhdunar. Pushchinskaya shkola-konferentsiya molodykh uchenykh: sb. tez. konf. [Biology – science of XXI century: 18th International Pushkin’s school-conference of young scientists: conference theses collection]. Pushchino, 2014, pp. 30–31.
5. Fishbein M., Levy R. J. and etc. The Journal of Thoracic Cardiovascular Surgery. 1982, 320 p.
6. Gengin M. T., Solov'ev V. B. Neyrokhimiya [Neurochemistry]. 2007, vol. 24, no. 2, pp. 138–142.
7. Lowry O. H., Rosebrought N. J., Farr A. L., Randall R. J. J. Biol. Chem. 1951, vol. 193, no. 1, pp. 265–275.
8. Lakin G. F. Biometriya: ucheb. posobie dlya vuzov [Biometrics: tutorial for universities]. Moscow: Vyssh. shk.,1990, 280 p.
9. Solov'ev V. B., Fedorova M. G., Lyubchenko O. D., Tatarinov V. F., Kupryushin A. S. Izvestiya vysshikh uchebnykh zavedeniy. Povolzhskiy region. Meditsinskie nauki [University proceedings. Volga region. Medical sciences]. 2014, no. 1 (29), pp. 27–36.
10. Solov'ev V. B., Fedorova M. G., Lyubchenko O. D., Tatarinov V. F. Izvestiya vysshikh uchebnykh zavedeniy. Povolzhskiy region. Meditsinskie nauki [University proceedings. Volga region. Medical sciences]. 2014, no. 3 (31), pp. 39–48.